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07 Sep 2016
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 MDMA (Methylenedioxymethamphetamine) is a preferred psychoactive substance perfectly located at the recreational drug 'Ecstasy'. Despite its frequent mention on television regarding deaths brought on by hyperthermia (overheating, frequently as a consequence of dehydration and excessive exercise) or hyponatremia (excessive consumption of water, leading to death), serious MDMA acute adverse events seem rare - with approximately two in a hundred thousand users using a reaction leading to death. The genuine health concern it appears, isn't for the short term perils of MDMA. But alternatively the alarmingly many habitual and long-term users of MDMA who regularly knock their neurotransmitters 'out of whack', every weekend.

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This long term abuse is worrying because MDMA is a somewhat new drug and therefore there are no studies on long-term MDMA users. Way more, MDMA includes a very unique basis of mechanism - significantly altering the serotonin systems in the brain. Furthermore, recent research conducted for both non-human primates and humans has found differences between MDMA user's brains and performance measures compared to non-MDMA users. MDMA causes a rise in the concentrations of three neurotransmitters inside the brain: serotonin (5HT), norepinephrine (NE), and dopamine (DA). Its primary release of serotonin has been said to be the cause of virtually all Ecstasy's positive side effects (empathy and euphoria), the depression users feel after while using drug and also the neurotoxic changes seen in MDMA user's brains.

These effects come as hardly surprising, as serotonin may be the neurotransmitter primarily responsible for regulating emotion, sleep, and mood. Current research on MDMA and the brain has brought conflicting and complicated results. Animal research shows much research on MDMA and potential damaging effects it's about the brain. There exists a huge library of literature demonstrating variants memory, language, and brain functioning between MDMA users and non-users; and non-human experiments showing irregular serotonin axon regrowth in a variety of close genetic relatives of ours. However, high of the existing research suffers from poor experimental design and experimental controls which are central to the scientific study and all too heavily associated correlation with causation.

Most research on ecstasy users may be categorized into two regions of study: neurofunctional measures and neurocognitive measures. Neurofunctional is loosely used to indicate measures of how the mind is working and measures in the concentration or density of neurochemicals. Neurocognitive measures refers to performance on standardized psychological tests of mental abilities. Research on ecstasy users supports associations between MDMA exposure and modifications in both neurofunctional and neurocognitive measures.


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